HPMC o loʻo taʻua o le hydroxypropyl methylcellulose.
O oloa a le HPMC e filifilia le cellulose cotton sili ona mama e fai ma mea mata ma e faia i le etherification faapitoa i lalo o tulaga alkaline.O le faagasologa atoa e maeʻa i lalo ole GMP ma le mataʻituina otometi, e aunoa ma ni mea aoga e pei o totoga o manu ma gaʻo.
HPMC meatotino:
HPMC oloa e le-ionic cellulose ether, foliga o le paʻepaʻe paʻepaʻe, odorless tasteless, soluble i le vai ma le tele polar organic solvents (e pei o le dichloroethane) ma le vaega talafeagai o ethanol / vai, propyl ava malosi / vai, ma isi. gaoioiga, manino maualuga ma mautu faatinoga.O le HPMC o lo'o i ai meatotino o le gel thermal, o le vai o le vai o oloa e fa'amafanafanaina e fausia ai le vai gel, ona fa'amavaeina lea pe a mae'a fa'amafanafana, fa'amatalaga eseese o le vevela gel oloa e ese.Suiga solubility ma le viscosity, o le maualalo o le viscosity, o le tele o le solubility, specifications eseese o le HPMC ei ai se eseesega faapitoa i ona meatotino, HPMC i le vai e le aafia i le taua PH.Lapopo'a: 100 mesh pass rate e sili atu nai lo le 100%.Tele density: 0.25-0.70g/ (e masani lava e uiga i 0.5g/), mamafa faapitoa 1.26-1.31.Fualili o le lanu: 190-200 ℃, vevela carbonization: 280-300 ℃.Tete'e i luga: 42-56dyn/cm i le 2% vaifofo vai.Faatasi ai ma le faateleina o mea e maua i le methoxyl, ua faaitiitia le mata o le gel, ua faateleina le solubility o le vai, ma ua faateleina foi le gaioiga i luga.O le HPMC o loʻo i ai uiga o le mafiafia, masima, maualalo le efuefu i totonu, faʻamautu PH, faʻamauina o le vai, faʻamautu tulaga, ata tifaga sili ona lelei ma le tele o teteʻe i le enzyme, faʻasalalau ma faʻatasi.
Talosaga HPMC:
1. Faʻapipiʻi laupepa: HPMC faʻaaogaina e pei o mea faʻapipiʻi ata i sauniuniga mautu, e mafai ona fai maʻaʻa, lamolemole ma matagofie ata, o le faʻaogaina o le 2% -8%.A maeʻa le faʻapipiʻiina, o le mautu o le sooupu i le malamalama, vevela ma le susu e faʻateleina;Le tofo ma le manogi, faigofie ona ave, ma le HPMC pigment, sunscreen, lubricants ma isi fetaui lelei o mea.Faʻapipiʻi masani: vai poʻo le 30-80% ethanol e faʻaumatia ai le HPMC, faʻatasi ai ma le 3-6% fofo, faʻaopoopo mea fesoasoani (e pei o le: vevela o le eleele -80, suauu castor, PEG400, talc, ma isi).
2. Enteric-soluble coating isolation layer: i luga o papa ma granules, o le HPMC coating e muamua faʻaaogaina e pei o le pito i lalo o le ufiufi o le vavae, ona faʻapipiʻiina lea i se vaega o le HPMCP enteric-soluble mea.HPMC ata tifaga e mafai ona faʻaleleia le mautu o le enteric-soluble coating agent i le teuina.
3. Sauniuniga fa'asa'oloto: fa'aaogaina le HPMC e fai ma sui e fa'aoso pore ma fa'alagolago i le ethyl cellulose e fai ma mea auivi, e mafai ona fa'atūina papama'a fa'aumi.
4. Mafiafi so'o ma colloid puipuiga pipi'i ma mata mataua: HPMC mo mafiafia sooupu masani fa'aaogaina fa'atonuga o le 0.45-1%.
5. Faʻapipiʻi: HPMC e pei o se faʻamaufaʻailoga lautele o le 2% -5%, faʻaaogaina e faʻaleleia ai le mautu o le faʻapipiʻi hydrophobic, faʻaaogaina masani o le 0.5-1.5%.
6. Fa'atuai fa'atuai, fa'atonu fa'amalolo ma so'o fa'amalolo.Suspension agent: o le masani masani o le suspension agent e 0.5-1.5%.
7. Meaʻai: HPMC e pei o le mafiafia o loʻo faʻaopoopoina i meainu eseese, meaʻai susu, meaʻai, meaʻai paleni, e pei o le mafiafia, faʻapipiʻi, emulsifier, suspension agent, stabilizer, vai faʻamauina sui, excifer, ma isi.
8. Faʻaaogaina i mea faʻalelei e pei o mea faʻapipiʻi, emulsifiers, mea fai ata tifaga, ma isi.
Taimi meli: Ian-14-2022