Meatotino o le hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose HPMC o se ituaiga e le-ionic cellulose fefiloi eter.E le pei o le ionic methyl carboxymethyl cellulose mixed ether, e le tali atu i metala mamafa.Ona o le eseesega o fua faatatau o le methoxyl anotusi ma le hydroxypropyl anotusi i le hydroxypropyl methylcellulose ma viscosities eseese, e tele ituaiga e eseese meatotino, mo se faataitaiga, maualuga methoxyl anotusi ma maualalo hydroxypropyl anotusi O lona faatinoga e latalata i le methyl cellulose, ae o le maualalo. methoxyl content ma maualuga hydroxypropyl content e latalata ile hydroxypropyl methyl cellulose.Ae ui i lea, i ituaiga taʻitasi, e ui lava naʻo se vaega itiiti o le hydroxypropyl group poʻo se vaega itiiti o le methoxyl group o loʻo i ai, o loʻo i ai se eseesega tele i le solubility i solvents organic poʻo le vevela o le flocculation i vaifofo vai.

(1) Mea e mafai ona solu o le hydroxypropyl methylcellulose

①Solubility o le hydroxypropyl methylcellulose i le vai Hydroxypropyl methylcellulose o le mea moni lava o se ituaiga o methylcellulose suia e propylene oxide (methoxypropylene), o lea o loo i ai pea lava meatotino tutusa e pei o le methyl cellulose E iai uiga tutusa o le vai malulu ma le vai vevela.Ae ui i lea, ona o le suiga o le hydroxypropyl vaega, o lona vevela gelation i le vai vevela e sili atu le maualuga nai lo le methyl cellulose.Mo se faʻataʻitaʻiga, o le viscosity o le hydroxypropyl methylcellulose solution vai ma le 2% methoxy content substitution degree DS = 0.73 ma le hydroxypropyl content MS = 0.46 o le 500 mpa·s i le 20 ° C, ma lona vevela gel E mafai ona latalata i le 100 ° C, ao. methyl cellulose i le vevela tutusa e na'o le 55°C.Ae mo lona soluble i le vai, ua matua faaleleia foi.Mo se faʻataʻitaʻiga, o le pulverized hydroxypropyl methylcellulose (foliga faʻapitoa 0.2 ~ 0.5mm i le 20 ° C ma le 4% vaifofo viscosity o 2pa•s e mafai ona faʻatau i I le vevela o le potu, e faigofie ona solu i le vai e aunoa ma le malulu.

②Solubility o le hydroxypropyl methylcellulose i solu faʻalaʻau O le solubility o le hydroxypropyl methylcellulose i solu faʻaola e sili atu foi nai lo le methylcellulose.Mo oloa i luga aʻe o le 2.1, maualuga-viscosity hydroxypropyl methylcellulose o loʻo i ai le hydroxypropyl MS = 1.5 ~ 1.8 ma le methoxy DS = 0.2 ~ 1.0, faʻatasi ai ma se tikeri atoa o le sui i luga aʻe o le 1.8, e soluble i anhydrous methanol ma ethanol solutions Medium, ma thermoplastic ma vai-soluble. .E mafai foi ona solu i totonu o le chlorinated hydrocarbons e pei ole methylene chloride ma le chloroform, ma solvents organic pei ole acetone, isopropanol ma le diacetone alcohol.O lona solubility i soluble organic e sili atu nai lo le solubility i le vai.

(2) O mea e aʻafia ai le viscosity o le hydroxypropyl methylcellulose O le faʻamautuina o le viscosity masani o le hydroxypropyl methylcellulose e tutusa ma isi cellulose ethers, ma e fuaina i le 20 ° C ma le 2% vaifofo vai e pei o le tulaga masani.O le viscosity o le oloa lava e tasi e faateleina i le faateleina o le faʻatonuga.Mo oloa e eseese mole mole mamafa i le faʻatonuga tutusa, o le oloa e tele mole mamafa mamafa e maualuga atu le viscosity.O lona sootaga ma le vevela e tutusa ma le methyl cellulose.A maualuga le vevela, e amata ona faʻaitiitia le viscosity, ae a oʻo i se vevela,

o le viscosity faʻafuaseʻi ona oso aʻe ma tupu gelation.O le vevela gel o oloa maualalo-viscosity e maualuga atu.e maualuga.O lona tulaga gel e le gata e fesoʻotaʻi ma le viscosity o le ether, ae e fesoʻotaʻi foi ma le fua faatatau o le methoxyl group ma le hydroxypropyl group i le ether ma le tele o le aofaʻi o le tikeri sui.E tatau ona maitauina o le hydroxypropyl methylcellulose o le pseudoplastic foi, ma o lona fofo e mautu i le vevela o le potu e aunoa ma se faʻaleagaina i le viscosity sei vagana ai le avanoa e faʻaleagaina ai le enzymatic.

(3) O le faapalepale masima o le hydroxypropyl methylcellulose Talu ai o le hydroxypropyl methylcellulose o se eter e le ionic, e le ionize i ala o vai, e le pei o isi ionic cellulose ethers, Mo se faataitaiga, carboxymethyl cellulose reacts ma uamea mamafa ions ma precipitates i fafo i le fofo.Ole masima lautele e pei ole chloride, bromide, phosphate, nitrate, ma isi mea faapena o le a le faʻafefe pe a faʻaopopo i lona vai vai.Ae ui i lea, o le fa'aopoopoina o le masima e iai sona aafiaga i le vevela o le fuga o lona vaifofo vai.A faʻateleina le faʻaogaina o le masima, e faʻaitiitia le vevela o gel.Pe a o'o i lalo le fa'asusuga o le masima i lalo ole vaega ole fuga, o le viscosity o le vaifofo e foliga mai e fa'atupula'ia.O le mea lea, e faʻaopoopoina se aofaʻi o masima., i le faʻaaogaina, e mafai ona maua ai le faʻafefeteina aafiaga sili atu le tamaoaiga.O le mea lea, i nisi o talosaga, e sili atu le faʻaaogaina o le faʻafefiloi o le cellulose ether ma le masima nai lo le maualuga maualuga o le faʻaogaina o le ether solution e ausia ai le faʻamalosi.

(4) Hydroxypropyl methylcellulose acid ma alkali resistance Hydroxypropyl methylcellulose e masani ona mautu i acids ma alkalis, ma e le afaina i le tele o le pH 2 ~ 12.E mafai ona tatalia se aofaiga faapitoa o Malamalama acids, e pei o le formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, ma isi. Ae o le acid concentrated ei ai le aafiaga o le faaitiitia o le viscosity.Alkalis pei o le suka, caustic potash ma le lime vai e leai se aoga i ai, ae e mafai ona faʻateleina le viscosity o le vaifofo, ona faʻaitiitia malie ai lea.

(5) Fa'afefiloi ole hydroxypropyl methylcellulose Hydroxypropyl methylcellulose solution e mafai ona fa'afefiloi ma vai-soluble polymer compounds e avea ma se toniga ma manino fofo ma maualuga viscosity.O nei polymer compound e aofia ai le polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinylsiloxane, hydroxyethyl cellulose, ma le methyl cellulose.O mea fa'alenatura maualuga mole mole e pei o le gum arabic, locust bean gum, karaya gum, ma isi mea e lelei foi le fetaui ma lona fofo.Hydroxypropyl methylcellulose e mafai foi ona faʻafefiloi ma le mannitol ester poʻo le sorbitol ester o le stearic acid poʻo le palmitic acid, ma e mafai foi ona faʻafefiloi ma le glycerin, sorbitol ma le mannitol, ma e mafai ona faʻaaogaina nei mea e pei o le hydroxypropyl methylcellulose Plasticizer mo cellulose.

(6) E mafai ona fa'afeso'ota'i feso'ota'i fa'atasi ma aldehydes i luga o le fogā'ele'ele'ele'ele'ele'ele vai-soluble ethers o le hydroxypropyl methylcellulose, ina ia fa'afefeteina nei ethers soluble vai i le vaifofo ma le mafai ona solu i le vai.O aldehydes e faʻaaogaina ai le hydroxypropyl methylcellulose e le mafai ona faʻaaogaina e aofia ai formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, ma isi. Pe a faʻaaogaina formaldehyde, e tatau ona gauai faʻapitoa i le tau o le pH o le vaifofo, lea e tali vave ai le glyoxal, o le mea lea e masani ona faʻaogaina ai le glyoxal e pei o se crosslink. sooupu i le gaosiga o alamanuia.O le aofaʻi o lenei ituaiga o fesoʻotaʻiga fesoʻotaʻiga i le fofo o le 0.2% ~ 10% o le tele o le eter, sili 7% ~ 10%, mo se faʻataʻitaʻiga, 3.3% ~ 6% o le glyoxal e sili ona talafeagai.E masani lava, o togafitiga

vevela o le 0 ~ 30 ℃, ma le taimi e 1 ~ 120min.E mana'omia ona faia le fa'agasologa o feso'ota'iga i lalo ole tulaga fa'ama'i.E masani lava, o le vaifofo e muamua faʻaopoopoina i le inorganic malosi acid poʻo le organic carboxylic acid e faʻafetaui ai le pH o le vaifofo i le 2 ~ 6, sili i le va o le 4 ~ 6, ona faʻaopopo lea o aldehydes e faʻatino ai le fesoʻotaʻiga fesoʻotaʻiga.O le vailaʻau faʻaaogaina o loʻo i ai le suka hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid poʻo le citric acid ma isi, lea e fautuaina ai le formic acid poʻo le acetic acid, ma le formic acid e sili ona lelei.O le acid ma le aldehyde e mafai foi ona faʻaopoopoina i le taimi e tasi e faʻataga ai le vaifofo e oʻo i se fesoʻotaʻiga fesoʻotaʻiga i totonu o le pH manaʻomia.O lenei tali e masani ona faʻaaogaina i le faʻagasologa o togafitiga mulimuli i le sauniuniga o le cellulose ethers.A maeʻa le cellulose ether e le mafai ona faʻaaogaina, e faigofie ona faʻaoga

20 ~ 25 ℃ vai mo le fufuluina ma le faʻamamaina.A faʻaaogaina le oloa, e mafai ona faʻaopopo mea alkaline i le vaifofo o le oloa e faʻafetaui ai le pH o le vaifofo e avea ma alkaline, ma o le a faʻamavae vave le oloa i le fofo.O lenei metotia e faʻaoga foi i le togafitiga o le ata pe a uma ona faia le cellulose ether solution i totonu o se ata tifaga e avea ai ma ata e le mafai ona faʻaaogaina.

(7) O le enzyme teteʻe o hydroxypropyl methylcellulose o le theoretically cellulose derivatives, e pei o vaega taitasi anhydroglucose, pe afai o loo i ai se vaega suitulaga mausali fusia, e le faigofie ona aafia i microorganisms, ae o le mea moni o le oloa maeʻa Pe a sili atu le tau sui. 1, o le a faʻaleagaina foʻi e enzymes, o lona uiga o le tikeri o le suitulaga o vaega taʻitasi i luga o le filifili cellulose e leʻo tutusa lelei, ma e mafai e microorganisms ona faʻaumatia i luga o le vaega anhydroglucose unsubstituted e fai ai sugars, e pei o meaʻai mo microorganisms e mitiia.O le mea lea, afai o le tikeri o le etherification suitulaga o cellulose faateleina, o le a faateleina foi le tetee i le tafia enzymatic o cellulose ether.E tusa ai ma lipoti, i lalo o tulaga pulea, o le hydrolysis taunuuga o enzymes, o le viscosity totoe o le hydroxypropyl methylcellulose (DS = 1.9) o le 13.2%, methylcellulose (DS = 1.83) o le 7.3%, methylcellulose (DS = 1.66) o le 3.8%, ma le hydroxyethyl cellulose e 1.7%.E mafai ona iloa o le hydroxypropyl methylcellulose o loʻo i ai se malosi malosi e tetee atu ai i le enzyme.O le mea lea, o le sili atu o le enzyme teteʻe o le hydroxypropyl methylcellulose, faʻatasi ma lona faʻasalalau lelei, mafiafia ma ata tifaga, e faʻaaogaina i vai-emulsion coatings, ma isi, ma e masani lava e le manaʻomia le faʻaopoopoina o mea faʻasao.Ae ui i lea, mo le teuina umi o le fofo poʻo le faʻaleagaina mai fafo, e mafai ona faʻaopopo mea faʻasao e fai ma puipuiga, ma e mafai ona fuafua le filifiliga e tusa ai ma manaoga mulimuli o le fofo.Phenylmercuric acetate ma manganese fluorosilicate o ni puipuiga lelei, ae o loʻo i ai uma le Toxicity, e tatau ona gauai atu i le taotoga.E masani lava, 1 ~ 5mg o le phenylmercury acetate e mafai ona faʻaopopo i le fofo ile lita ole vailaʻau.

(8) O le faʻatinoga o le hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose o loʻo i ai mea sili ona lelei e fai ata tifaga.O lona vaifofo vai po'o se vaifofo so'o so'o e ufiufi i luga o se ipu tioata, ma e le lanu ma manino pe a uma ona mago.Ma ata tifaga faigata.E lelei le susū e tete'e ma tumau mausali i le vevela maualuga.Afai e faʻaopoopoina le plasticizer hygroscopic, e mafai ona faʻaleleia lona faʻalauteleina ma le fetuutuunai.I tulaga o le faʻaleleia atili o le fetuutuunai, o mea faʻapipiʻi e pei o le glycerin ma le sorbitol e sili ona talafeagai.E masani lava, o le fofo o le 2% ~ 3%, ma le aofaʻi o le plasticizer o le 10% ~ 20% o le cellulose ether.Afai e maualuga tele le mea o loʻo i totonu o le plasticizer, o le a faʻaitiitia le faʻamamago colloidal i le maualuga o le susu.Le malosi faʻamalosi o le ata tifaga ma

plasticizer faaopoopo e sili atu le tele nai lo le leai o plasticizer, ma e faateleina i le faateleina o le aofaiga faaopoopo.Ae mo le hygroscopicity o le ata, e faʻapupulaina foi i le faʻateleina o le aofaʻi o le plasticizer.